Coronary heart disease is difficult in the morning and relief in the afternoon to consider with the two peaks and valleys of blood pressure in a day or and take the peak concentration of coronary heart disease drugs. Two peaks that during the 24h blood pressure fluctuation there will be two peaks, the first peak appeared in the morning 7:00-9:00, the second peak appeared in the afternoon 2:00-4:00, generally the second peak will be higher than the first peak; a valley that is the lowest value of blood pressure in a day. The 1st trough occurs from 12:00 noon to 2:00 pm. When blood pressure is high in the morning, patients with coronary heart disease will experience dizziness, headache, palpitations and other symptoms. When the trough period arrives in the afternoon, the blood pressure drops and the symptoms can be relieved. Patients take drugs for coronary heart disease in the morning, the drug reaches the peak concentration in the afternoon, the best effect of the drug in the afternoon, can also appear in the morning of coronary heart disease is difficult to relieve in the afternoon. Coronary heart disease patients should pay attention to regular review, and regular monitoring of symptomatic changes, if uncomfortable symptoms, it is recommended to consult a doctor in a timely manner. Daily attention should be paid to moderate exercise, control blood pressure and quit smoking and alcohol, and at the same time to maintain a happy mood, avoid excessive emotional fluctuations.