Cystic nodular acne, which is also referred to as cystic or nodular acne, requires a combination of medication and physical therapy for treatment to eliminate. 1. Medication: (1) Topical medication: Topical medication with the ability to dissolve keratin and soften keratin can improve the symptoms of cystic nodular acne, such as retinoic acid cream, fusidic acid cream and other antibiotic ointment, and benzoyl peroxide cream and so on. (2) Oral medication: Retinoids have the effect of reducing sebaceous gland tissues, inhibiting sebaceous gland activity, and inhibiting Propionibacterium acnes, and are suitable for refractory nodular acne, and commonly used medications include isotretinoin soft capsules. Minocycline tablets and doxycycline tablets are given according to the course of treatment for anti-infection treatment, which is also the first choice for treating cystic nodular acne. (3) Local closure therapy: choose glucocorticoid drugs for local closure of cystic nodules, which can play an anti-inflammatory effect, and the more commonly used drugs are Triamcinolone acetonide, prednisone and so on. 2. Physical therapy: The use of laser therapy and red and blue light irradiation can release inflammatory substances and promote the dissipation of local inflammation, which has a certain auxiliary therapeutic effect on cystic nodular acne. Cystic nodular acne is a more serious type of acne, the specific treatment plan should be decided after a doctor’s consultation, do not use your own medicine.