Epiphyseal closure is categorized into physiologic and pathologic closure. Physiological closure differs between men and women, with women usually around 14 to 16 years of age and men around 16 to 18 years of age. Pathological causes may lead to earlier epiphyseal closure. 1. Physiologic closure: Under normal growth and development, the epiphysis will gradually close under the regulation of human hormones. Females enter puberty earlier, so most female epiphyses close between the ages of 14 and 16; male epiphyses usually close between the ages of 16 and 18. The closure of the epiphyses indicates that there will be no significant change in height. 2. Pathological closure: some special circumstances may lead to early closure of the epiphysis, such as epiphyseal fracture in childhood, local infections, excessive fatigue, etc. These circumstances will cause the destruction of the ossification center of the long bones, cartilage ossification, hormonal disorders and other pathological changes, which may lead to pathological closure of the epiphysis.