If the ratio of pepsinogen 1 and 2 is greater than 7.5 and gastrin 17 is high, if the ratio is not too high and there are no obvious symptoms, we can follow up and observe, if the ratio is obviously elevated or there are related digestive symptoms, we can improve the breath test, gastroscopy and other investigations in order to clarify the cause of the disease.
Pepsinogen is synthesized by the main cells of the acid-producing glands and is the precursor of pepsin, which is divided into 2 subgroups according to its biochemical properties and immunogenicity, i.e., pepsinogen I and pepsinogen II. Gastrin 17 is a gastrointestinal hormone secreted by gastric sinus and duodenal G-cells, which is able to regulate the function of the digestive system and maintain the structural integrity of the mucous membrane of the gastrointestinal tract.
1. Follow-up observation: the ratio of pepsinogen 1 and 2 is normally between 3.0 and 7.5, which is often used as a tracing indicator for atrophic gastritis and a screening method for early detection of gastric cancer.
When the ratio is greater than 7.5 and the ratio is not too high, gastrin 17 is on the high side, and there are no obvious gastrointestinal symptoms such as nausea, vomiting, abdominal distension, diarrhea, etc., the patient can be followed up regularly for observation.
2. Further examination: If there are obvious digestive symptoms or the ratio of pepsinogen 1 and 2 is obviously elevated and gastrin 17 is high, it may be due to the damage of the gastric mucosa or Helicobacter pylori infection, and it is necessary to judge the condition through carbon 13 or 14 breath test, electronic gastroscopy, digestive tumor markers and other examinations in a timely manner.
When abnormalities of pepsinogen 1 and 2 ratio and gastrin 17 are detected, it is recommended to consult a gastroenterologist in time for further decision-making under the guidance of a specialized physician.