Black pigment on lips belongs to melanin deposition, and the common causes include cellular nevus, melanosis, acanthosis nigricans, hyperpigmentation, etc. The methods of removing it include laser treatment, medication, general treatment, etc., and it is necessary to choose the appropriate treatment according to the cause of the disease under the guidance of the doctor for treatment. 1.Cellular nevus:This disease is a benign skin tumor of melanocyte origin, generally no special treatment is needed after diagnosis, surgical treatment is considered when necessary, and histopathological examination is done after operation. 2. Melanosis: manifested as gray-purple grid pigmentation plaques. After the diagnosis of this disease, it can be treated with topical depigmenting agents, such as hydroquinone cream, compound arbutin cream, etc.; it can also be improved by combined laser treatment; oral vitamin C, tranexamic acid, etc., to reduce the production of melanin. 3. Acanthosis nigricans: after the diagnosis of this disease, active treatment of primary diseases, such as tumors, endocrine diseases, etc., the treatment of limited lesions can be topical retinoic acid, topical vitamin D analogues, such as topical retinoic acid, hydroquinone and fluoride easy triple cream, carbotriol cream, etc.; local can also be used in combination with urea, salicylic acid, ethanoic acid skin resurfacing and laser therapy. 4. Hyperpigmentation: Due to the richness of blood vessels around the mouth, some people will have dark color around the mouth, which is a normal physiological phenomenon. Improvement of this situation can be achieved through regular cleaning of perioral keratin, C6 and other phototherapy. It is recommended that patients according to their own situation, timely to the regular hospital dermatology consultation, follow the doctor’s instructions for a clear diagnosis, timely treatment, the use of drugs need to strictly comply with the doctor’s instructions for medication, not blindly self-medication.