Usually there is no fastest and most effective treatment for nocturnal coughing. Nocturnal coughing may be caused by lung diseases, such as chronic obstructive pulmonary disease (COPD), cough variant asthma, etc.; cardiovascular diseases, such as left heart failure, etc.; and digestive diseases, such as gastroesophageal reflux disease (GERD), etc. The patients can be relieved by general treatment medication and surgical treatments. 1. Chronic obstructive pulmonary disease (COPD): COPD patients should quit smoking and stay away from polluted environment. Patients can use bronchodilators, such as salmeterol, aminophylline, etc.; glucocorticosteroids, such as fluticasone, budesonide, etc., accompanied by bacterial infections, patients can take cefazoxime, levofloxacin and other drugs for treatment. For patients with severe cough at night, you can only use drugs such as aminoglutethimide to stop coughing and resolve phlegm. 2. Cough variant asthma: due to the increased excitability of the vagus nerve at night, it can be manifested as violent cough at night, which can be relieved by inhalation of bronchodilators such as salbutamol, formoterol, inhalation of glucocorticosteroids such as budesonide and other medicines, and also oral antiallergic medicines such as menglustrol sodium, loratadine and so on. 3. Left heart failure: patients should pay attention to monitor their weight changes, reduce sodium intake, limit physical activity. Patients can follow the doctor’s instructions to use diuretics, such as furosemide, hydrochlorothiazide, etc.; β-blockers, such as metoprolol, etc.; vasodilator drugs, such as sodium nitroprusside, nitroglycerin, etc. for treatment. 4. Gastroesophageal reflux disease (GERD): patients should avoid eating within 2 hours before bedtime, and the head of the bed can be raised 15~20cm when sleeping. Patients can take acid-suppressing drugs, such as omeprazole, lansoprazole, etc.; gastrointestinal stimulants, such as domperidone, mosapride, etc.; antacids, such as sodium bicarbonate, aluminum hydroxide, etc. for treatment, and severe cases can be treated surgically. Nocturnal cough may also be caused by other diseases, and it is recommended that the patient consult a doctor in time and actively cooperate with the doctor’s treatment. The above medications should be used under the supervision of a physician.