The eyes can be swollen when you wake up from sleep in normal people, but it can also be caused by blepharitis, conjunctivitis, etc. You should consult a doctor in time to clarify the cause of the disease and then treat it. 1. Physiological situation: Normal people in the late night, drink a lot of water before going to bed will appear when waking up eyes, such people should maintain sufficient sleep time, drink less water before going to bed, carry out appropriate physical exercise, generally do not need special treatment. 2. blepharitis: sleep waking up with swollen eyes may also be staphylococcus and other infections caused by acute suppurative inflammation, the patient will also have local redness, pain, can follow the doctor’s instructions to use erythromycin, ofloxacin, etc. for treatment. 3. Conjunctivitis: Conjunctivitis caused by infection, external stimuli, can also cause waking up with swollen eyes, the patient may also have red eyes, tearing, itching and other discomforts, should be timely medical examination to clarify the specific conditions to be treated. Waking up with swollen eyes after resting for a long time can not be relieved or accompanied by eye pain and other discomforts, it is recommended to consult a doctor as soon as possible for examination and treatment.