Taking liver protection tablets for liver discomfort may be caused by primary liver disease, or it may be caused by the adverse reaction of medication, which can be intervened by stopping the medication, adjusting the lifestyle and dietary habits, or taking other medications. Liver Protecting Tablets is a kind of proprietary Chinese medicine, mainly composed of Chai Hu, Yin Chen, Ban Lan Gen, Wu Wei Zi, etc. It has the efficacy of dispersing the liver and regulating the qi, invigorating the spleen and eliminating the food, and can be used to lower the transaminase and treat the diseases of chronic hepatitis and early cirrhosis of the liver. The contraindications and adverse reactions of Liver Protector Tablet are not clear, but long-term use of the drug may increase the burden on the liver and kidneys, leading to discomfort in the liver area and even causing drug-related liver injury. Usually the symptoms will be relieved after stopping the drug. Liver discomfort after oral hepatoprotective tablets may also be caused by primary diseases, at this time, according to the cause of the disease by taking other drugs to regulate. If caused by viral hepatitis, can take entecavir and other antiviral drugs; if caused by alcoholic liver, fatty liver, etc., can take reduced glutathione, S-adenosylmethionine, silymarin and other drugs to treat. In addition, patients should also pay attention to adjust the lifestyle and dietary habits, ensure enough rest, avoid late nights, alcoholism, overwork, etc., maintain a light diet, nutritional balance, avoid eating greasy and other difficult to digest food. At the same time, pay attention to the appropriate strengthening of sports, keep a happy mood, enhance their physical fitness. Oral liver tablets after the liver uncomfortable symptoms continue not to ease, it is recommended to timely medical treatment, under the guidance of a professional physician to identify the cause of the disease, targeted treatment. Drugs need to be taken in strict accordance with the doctor’s instructions, not self-medication, so as not to delay the condition.