Maternal-origin diabetes syndrome is a congenital abnormality caused by a pregnant woman who has diabetes that was not controlled prior to pregnancy resulting in hyperglycemia during gestation, a congenital abnormality caused by intrauterine damage to the fetus. In the past, this condition was usually referred to as congenital maternal origin diabetes syndrome. Gestational diabetes mellitus caused by physiologic metabolic changes during pregnancy does not usually result in severe fetal malformations except in congenital megacystis. Gestational diabetes mellitus and maternal diabetes mellitus syndrome have recently been collectively referred to as diabetic embryopathy. Hyperglycemia is now considered to be the main cause of fetal malformations. Hyperglycemia in early pregnancy can result in impaired development of the embryonic yellow sac. Hyperglycemia can affect the metabolism of inositol, which in turn can lead to abnormal morphological development of the embryo. CLINICAL FEATURES: Caudal bone degeneration is a specific clinical manifestation of maternal diabetes mellitus syndrome. Congenital megacystis is the main clinical feature of gestational diabetes mellitus. The main congenital malformations include: 1, other skeletal system malformations: varying degrees of sacral and coccygeal bony defects, in severe cases, there may be sacral body defects, flat hips, short and underdeveloped legs, and horseshoe inversion feet; 2, cardiovascular malformations: such as transposition of the great arteries, ventricular septal defect, atrial septal defect, single ventricle, and pulmonic stenosis; 3, neurological abnormalities: such as aphthous encephalopathy, anencephaly, and spina bifida, etc.; 4, spinal bifida, etc.; 5, and other congenital abnormalities. Spina bifida, etc.; 4, urinary tract anomalies: such as polycystic kidney, renal dysplasia, double urethra; 5, gastrointestinal anomalies: anal atresia, rectal atresia, left colonic dysplasia. Treatment: 1, dietary control: is one of the most important therapeutic methods for the treatment of patients with gestational diabetes mellitus. It is very important to regulate the diet of pregnant women and increase the calories during pregnancy to accommodate the metabolism of the placenta and fetus. 2, drug treatment: through the diet control of blood glucose still can not reach the normal level, should be given drug treatment. Sulfonylureas can affect the fetus through the placenta, and biguanides should not be used in pregnant women. Prevention: 1. Strict control of blood glucose in the normal range before and during early pregnancy is essential to reduce the incidence of congenital diabetes mellitus syndrome. 2, Routine diabetes screening should be performed for women who are pregnant. 3, Regular ultrasound examination should be carried out to understand the development of the fetus and to detect the occurrence of fetal malformations in a timely manner.