A high level of anti-streptococcal hemolysin may be due to rheumatic disease, kidney disease, connective tissue disease, and heart disease. Anti-streptococcal hemolysin is a specific test for group A hemolytic streptococci. 1. When the anti-streptococcal hemolysin is high, it may be caused by rheumatic diseases, such as rheumatoid arthritis and rheumatoid arthritis, both of which will have high anti-streptococcal hemolysin index. 2. Some renal diseases may also have elevated anti-streptococcal hemolysin, such as glomerulonephritis and acute nephrotic syndrome. 3. Systemic lupus erythematosus (SLE), a connective tissue disease, may also be associated with elevated antistreptococcal hemolysin. 4. Anti-streptococcal hemolysin is also elevated in viral myocarditis. Overall, high anti-streptococcal hemolysin is harmful to the body, and it is recommended to go to the hospital in time for consultation and timely treatment under the guidance of the doctor.