Hepatic flexure syndrome of the colon is a syndrome of related symptoms, not necessarily cancer, but also may be caused by inflammation and adhesion, irritable bowel and so on. Colonic hepatic flexure syndrome belongs to the category of irritable bowel syndrome, which is mainly caused by spasms leading to dysfunction of colon function, and the lesion mainly occurs in the hepatic flexure of the colon, and this series of symptomatic manifestations is called colonic hepatic flexure syndrome. In terms of clinical manifestations, it is mainly manifested as dull pain in the upper abdomen or right upper abdomen when standing upright, nausea, loss of appetite, which usually occurs during the daytime, and the symptoms are aggravated after standing for a long time; in this case, it is necessary to differentiate with chronic cholecystitis, and then with cholelithiasis. Generally, it can be complicated with such diseases as dyspepsia and intestinal obstruction. Colorectal cancer can be accompanied by colorectal hepatic flexure syndrome, but the latter is not always triggered by the former, but can also be caused by inflammatory adhesions. Patients suffering from colorectal hepatic flexure syndrome are recommended to go to the gastroenterology department of regular hospitals for examination in time, and take medicines under the guidance of doctors, not self-medication.