The dosage of Febuxostat is from 20mg to 80mg, used for long-term uric acid lowering treatment for patients with gout and hyperuricemia, taking Febuxostat need to review liver and kidney function regularly. The initial dose of Febuxostat is 20mg at the beginning of uric acid-lowering drug therapy, which may lead to a rapid decrease in blood uric acid value and trigger gouty arthritis, therefore, it is recommended that the initial dose of Febuxostat is 20mg, and the dose is gradually increased by 20mg each time according to the blood uric acid value after 4 weeks of administration, and the maximum dose is 80mg per day, and the lowest effective dose is maintained after the blood uric acid value reaches the standard (<360µmol/L). No dose adjustment of febuxostat is necessary in patients with mild to moderate hepatic or renal insufficiency; it should be used with caution in individuals with severe hepatic insufficiency and severe renal insufficiency. Febuxostat has adverse reactions such as hepatic impairment, nausea, arthralgia, and rash; it is contraindicated in patients who are allergic to the drug and are being treated with azathioprine or mercaptopurine. Pay attention to monitor liver and kidney function during the use of the drug. It is recommended to follow the doctor's instructions to use the drug, if there is any discomfort manifested during oral intake, promptly consult a doctor.