Chronic inflammation of the cardia mucosa refers to chronic inflammatory lesions of the mucosa connecting the stomach and esophagus caused by different etiologies. Chronic inflammation of cardia mucosa is a kind of chronic gastritis, which is the most common disease in primary gastroenterology outpatient clinics. Its etiology includes Helicobacter pylori infection, dietary and environmental factors, drug factors, and immunologic factors. Most of the patients have no obvious symptoms, and those who have symptoms mainly manifest epigastric pain, abdominal distension, early satiety, belching (burping) and other dyspeptic symptoms, and some of them are accompanied by anxiety, depression and other psychosomatic symptoms. Gastroscopy and biopsy histopathology are the main means of diagnosis and differential diagnosis of chronic inflammation of cardia mucosa. The main treatments for chronic inflammation of cardia mucosa include lifestyle interventions, medications, and traditional Chinese medicine and other therapies, which help to control the progression of the disease and thus improve the quality of life. In the presence of the above mentioned symptoms of discomfort, one should consult a doctor and follow the treatment prescribed by the doctor.