Pediatric nephrotic syndrome relapse first need to consider the cause of relapse, if it is caused by infection, need to carry out anti-infection treatment and continue the original treatment; if it is caused by hormone resistance, need to actively consult the doctor, adjust the treatment program. If the recurrence is caused by infection, then anti-infection treatment, such as oral penicillin, etc., when the infection improves after the urinary protein will generally turn negative, then the original treatment program can still continue to use ‘If the anti-infection treatment after the urinary protein is still positive, may be related to the hormone to reduce the dosage of too fast, the hormone should be adjusted in a timely manner. If it is due to hormone resistance and frequent relapses, then the existing treatment program needs to be adjusted, you need to improve the quantitative urine protein and other tests, under the guidance of the doctor to increase the dosage of hormones or add cyclophosphamide, cyclosporine A and other drugs, and need to be regularly reviewed in the hospital to clarify the effectiveness of the treatment. All of the above drugs should be used under the guidance of doctors, avoid self-medication. Pediatric nephrotic syndrome relapse must be taken seriously, actively consult the doctor, and be evaluated and handled by a specialist.