High neuron-specific enolase may be caused by cerebral nerve injury, small cell lung cancer, neuroblastoma and so on. 1. Cerebral nerve injury: it is mostly seen in encephalitis or cerebrovascular disease, and may also be caused by severe intracranial injury leading to cerebral nerve injury, and neuron-specific enolase will also be high. 2. Small cell lung cancer: as neuron-specific enolase is a common tumor marker for small cell lung cancer, and it is the most sensitive and specific, if the value is high, it is very likely to have small cell lung cancer. 3. Neuroblastoma: mostly seen in infants and children under 2 years old, due to the tumor will secrete neuron-specific enolase, resulting in elevated values. Higher values of neuron-specific enolase may also be caused by other reasons. It is recommended to cooperate with doctors to take examinations, make a clear diagnosis and then target treatment.