You can take sildenafil with cold medicine, but it should be regulated under the guidance of a doctor. Cold medicines are mainly drugs for treating cold symptoms, while sildenafil is mainly used for treating erectile dysfunction, there is no conflict between the two, and they can be taken together under the guidance of a doctor. Sildenafil can cause headache, flushing, dizziness, nasal congestion, dyspepsia, visual abnormalities and other adverse reactions, it should be noted that patients who are allergic to sildenafil or any other excipients in the product are prohibited from using. Sildenafil should not be taken together with Levocetirizine, nitrate drugs such as nitroglycerin, isosorbide mononitrate and other drugs, because the combination can enhance the antihypertensive effect of the above drugs, resulting in low blood pressure. It is recommended that people who take cold medicine, if they need to take sildenafil, should ask the doctor in time, under the guidance of the doctor to use the drug, not blindly self-medication, so as not to cause adverse consequences.