Cranial defects are a common disorder in neurosurgery and are often caused by cranio-cerebral trauma caused by traffic accidents, production safety accidents, falling objects, falls from height, fights and brawls, or left behind after craniotomy due to high cranial pressure and inability to return the bone flap immediately. This cranial defect may occur in all parts of the skull, including the frontal, temporal, occipital, and top parts. All cranial defects require the use of certain artificial materials to fill and repair the cranial defect area to restore the complete closed cranial cavity and restore a stable intracranial environment. The repair requires a detailed scientific diagnosis and evaluation of the patient to exclude contraindications to surgery, a 3D CT scan of the patient’s skull, 3D reconstruction and design of the PEEK material, and precise personalization of the patient’s bone window data to produce a PEEK plate that can be seamlessly and precisely embedded in the bone window to achieve good repositioning. Currently, our team performs PEEK skull repair, which is an excellent way to repair skull defects. The team not only uses PEEK, a very advanced material, as the skull repair material, but also continuously improves and upgrades the technology and material optimization design, and introduces the concept of aesthetic plastic surgery, not only to restore the integrity of the skull and the cranial cavity to close and stabilize, but also to treat the factors affecting the appearance of aesthetic plastic surgery, to achieve the organic unity of anatomical integrity, functional perfection and aesthetic appearance.