Whether stage III nasopharyngeal cancer can be cured is related to the patient’s age, malignant degree of tumor and other factors, and the five-year survival rate is generally 68%. Nasopharyngeal cancer stage III is generally in the locally advanced stage of malignant tumor, so it is more difficult to be cured completely, but once diagnosed, the prognosis will be improved after actively cooperating with doctors for surgical treatment combined with radiotherapy and chemotherapy. The five-year survival rate of stage III nasopharyngeal cancer is generally 68%. The prognosis of stage III nasopharyngeal cancer is related to the patient’s age, malignant degree of tumor and allergy to chemotherapy drugs, etc. The younger the patient is, the more sensitive he is to chemotherapy drugs and the lower the malignant degree of the tumor is, the better the prognosis is, and on the contrary, the worse the prognosis is. Patients diagnosed with stage III nasopharyngeal cancer should actively cooperate with doctors in treatment, maintain a healthy lifestyle and a good mindset, all of which can help improve the prognosis.