Melanosis on upper lip needs to be treated according to the specific cause, such as nevus, abnormal melanin deposition, fungal infection, etc. After clear diagnosis, general treatment, medication, physical therapy or surgery will be taken. 1. Melanotic nevus: the presence of melanotic nevus on the upper lip may be mistaken for melanosis. Melanotic nevus belongs to benign hyperplasia, and surgical treatment can be chosen if necessary. 2. Abnormal melanin deposition: Frequent lip licking, lip tearing, lip biting and other behaviors, or congenital factors, post-inflammatory hyperpigmentation and so on, can lead to the phenomenon of melanin deposition on the upper lip. You can use laser to break down the melanin and improve the symptoms. 3. Fungal infections: Fungal infections on the upper lip can also cause the phenomenon of melanosis, you can use antifungal drugs, such as tretinoin econazole cream, etc., to control the infection. There are many reasons for the melanosis of the upper lip, after the symptoms, it is recommended to go to the hospital in time to improve the examination, the above drugs need to be used in accordance with the doctor’s instructions, not to be used indiscriminately, so as not to lead to adverse consequences.