Positive anti-nRNP antibodies are mainly found in patients with mixed connective tissue diseases. Anti-nRNP antibodies are generally used for diagnosis and differential diagnosis of connective tissue diseases, which are not necessarily rheumatoid, but may also be systemic lupus erythematosus, desiccation syndrome, polymyositis, and so on. 1. Systemic lupus erythematosus: the occurrence of this disease is related to genetic factors, drug factors, infections and sex hormones. The disease is easy to recur after illness. Oral cyclophosphamide, azathioprine, cyclosporine and so on can be taken as prescribed by doctors. 2. Dry syndrome: it may be related to the patient’s autoimmunity and genetic factors, and may also be related to viral infections. Use bromhexine tablets, cevimeline, celecoxib, etc. as prescribed by the doctor. 3. Polymyositis: may have excessive drinking habits, in addition to viral infections and drug factors. Commonly used drugs include methylprednisolone. It should be used according to the doctor’s prescription. If the anti-nRPN antibody is positive, it is not necessarily rheumatoid, it is recommended to consult the rheumatology and immunology department in a timely manner, complete the relevant examinations under the guidance of the doctor to clarify the cause of the disease and then symptomatic treatment.