Knee pain calf soreness may be related to trauma, knee joint lesions, lower extremity vascular lesions. Knee calf trauma causes soft tissue damage, local capillary rupture and bleeding, it will cause soreness and pain and other symptoms. Knee joint lesions, such as osteoarthritis, rheumatoid rheumatoid arthritis, gouty arthritis, joint deformation in the later stages of the lesion will appear in the knee joint and calf soreness and pain and other symptoms. Lower extremity vascular disease, such as venous thrombosis, varicose veins will cause reflux obstruction, there will be knee leg and other places such as soreness and swelling symptoms. If the knee and calf soreness, it is recommended that the patient go to the hospital, improve the examination, regular treatment.