Conservative treatments for duodenal cancer include chemotherapy and radiotherapy, which are generally applicable to patients with advanced stage, and the most important treatment method is still surgical resection. Duodenal cancer can be treated with chemotherapy using gemcitabine, oxaliplatin, irinotecan, fluorouracil and other drugs, which mainly inhibit the proliferation of tumor cells, and can also be treated with local radiotherapy, which is generally applicable to patients with advanced stage. The preferred treatment for duodenal cancer is surgical resection, such as pancreatic head duodenectomy, most of the stomach resection of duodenal bulb and so on. After timely surgical resection of duodenal cancer, the prognosis is better and the 5-year survival rate is also higher, so surgical treatment is generally recommended. It is suggested that duodenal cancer patients, listen to professional doctor’s advice and choose appropriate treatment to avoid adverse consequences.