Wild-type glioma is one of the more malignant glioblastoma subtypes in the WHO subtypes.
1. Currently, glioblastoma is classified into two types: IDH wild-type and IDH mutant. IDH wild-type usually develops at an age of >55 years, with a median age of onset of 62 years, and exhibits glioblastoma features at the time of initial diagnosis, consistent with primary glioblastoma, with a shorter history of the disease (average of 4 months), and a poorer prognosis (median overall survival (OS) of <15 months).
2. The WHO classification criteria for glioblastoma (IDH wild-type) are: diffuse, infiltrative growth, IDH wild-type, high cell density, common nuclear schizophrenia, accompanied by vascular hyperplasia or necrosis, TERT promoter mutation, EGFR amplification, chromosome 7 with copy number change of chromosome 10, or a combination of these phenotypes.
Patients with wild-type glioma need to go to the hospital in time to avoid progression of the disease, or even life-threatening.