The causes of knee pain may be related to degenerative joint disease, meniscus injury, arthritis and other factors, according to the specific circumstances of the choice of life interventions, drug therapy and surgical treatment. 1. Degenerative joint lesions: because of degenerative joint lesions caused by knee pain when the knee is not straightened, the treatment is to pay attention to strengthen the movement, strengthen the muscle strength around the joints, reduce the burden on the joints, and pay attention to weight control at the same time. 2. Meniscus injury: For patients with meniscus injury that causes pain when the knee is not straightened, they can follow the doctor’s instructions to use ibuprofen extended-release capsules, diclofenac sodium extended-release tablets and other medications for pain relief, and they need to cooperate with the doctor to give meniscus suturing and meniscoplasty treatment. 3. Arthritis: For severe arthritis, joint function seriously impaired caused by the knee can not straighten a straight pain, in addition to the choice of ibuprofen medication for pain relief, but also can be given to the arthroscopic minimally invasive joint repair, joint replacement, joint fusion and other ways of treatment. It is recommended that patients should go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment.