The skull is a very important bone in our head, it is the barrier between our brain and the outside world and protects the normal operation of the tissues in the brain. The skull may be defective for many reasons, such as accidental fall from a height, being hit by a heavy object that easily causes brain damage, or because of the lesion of the skull itself that requires debridement surgery, thus causing a defect in the skull. Generally speaking, if the defect area is more than 3cmX3cm, skull repair is necessary. If you don’t go to the hospital for repair in time, it will be very harmful, not to make the brain tissue get a good protection, thus affecting the normal operation of the human body, and long-term will make patients have a great psychological barrier, because the collapse or expansion of the brain feel different from ordinary people, resulting in low self-esteem, not confident, thus greatly affecting the life and work of patients. Therefore, patients with large skull defects should undergo skull repair surgery as soon as possible within three months after surgery. With the advancement of medical science, more and more cranial repair materials are gradually available for use. Plexiglass, light apatite and calcium phosphate cement materials, which were once used in clinical practice, are gradually withdrawn from the medical arena due to their poor clinical results. The commonly used material for cranial repair today is titanium mesh, which is also a quality material with long-lasting application and good results. However, the metallic properties of titanium mesh often have consequences for patients such as sensitivity to cold and heat reactions and CT image errors. Thanks to the efforts of medical researchers, a new type of cranial repair material has been applied above the clinical level, and that is PEEK material. The material is known as polyether ether ketone, a polymer biomaterial that is extremely close to human cranial bone in terms of elasticity, heat transfer, hardness, and stability, etc. The use of three-dimensional shaping of the PEEK bone plate can be completely compatible with the cranial structure, without worrying about precision and aesthetics. Numerous clinical cases have shown that there are no discomfort or complications associated with PEEK cranial bone repair materials, so PEEK is currently the better choice for cranial bone repair.