The high risk of trisomy 21 is not a lie, it is a result of the Down’s syndrome screening test. The accuracy of the results of Down’s syndrome screening is not 100%. When a woman is found to have a high risk of trisomy 21, she should cooperate with her doctor to do further testing, which can be done by non-invasive DNA or amniocentesis, so as to clarify whether there is any chromosomal abnormality in the fetus. Because the accuracy of the results of Down’s syndrome screening is not very high, even if the test is low risk, the possibility of fetal chromosomal abnormalities can not be completely ruled out, especially for older pregnant women, non-invasive DNA or amniocentesis can be carried out, so as to clarify whether the fetus has chromosomal or genetic abnormalities. If a pregnant woman is diagnosed with fetal chromosomal or genetic abnormalities, she needs to cooperate with her doctor for appropriate treatment if necessary.