Lying down and feeling something in the stomach may be the cause of reflux symptoms, there are a variety of causes, need to treat the cause, mainly through drug treatment. Lying down feeling something in the stomach may be mental factors, indigestion, gastritis, gastric ulcer, Helicobacter pylori infection, etc., according to the cause of the emotional adjustment, take to promote digestion, antacids, gastric mucosa protection drugs, anti-Helicobacter pylori drugs and other treatments. 1. Mental factors: stress, anxiety, depression and other causes of autonomic nervous disorders, generally soothing emotions, release the pressure can be gradually relieved. 2. Dyspepsia: drugs such as mosapride and pepsin can be given to promote the emptying of food as soon as possible. 3. Gastritis: gastric mucosal damage, inflammation affects the digestion of food, can be given pantoprazole, ranitidine and other antacids combined with gastric mucosal protection drugs, such as sodium bicarbonate, aluminum sulfate, etc. to promote gastric mucosal repair. 4. Gastric ulcer: If there is Helicobacter pylori infection, amoxicillin, clarithromycin, rabeprazole, colloidal bismuth pectin and other medications can be given to treat anti-Helicobacter pylori infection, the course of 10-14 days, and at the same time be given to the proton pump inhibitors, such as rabeprazole to protect the gastric mucosa, the course of 6-8 weeks. Lying down and feeling something in the stomach, it is recommended to seek timely medical treatment, improve gastroscopy and other related examinations, to clarify the cause of the disease, and use medication under the guidance of the physician, do not self-medication, so as not to delay the condition.