Lumbar protrusion combined with pyriformis syndrome can take bed rest, avoid bending and weight bearing and other general treatment, hot compresses, infrared and other physical therapy, anti-inflammatory and pain relief drugs, if necessary, surgery. 1. General treatment: in the acute stage, it is recommended that the patient should take bed rest, avoid bending and weight bearing, avoid exertion, and wear a waist cuff if necessary. 2. Physiotherapy: hot compresses, infrared light on the local physiotherapy, promote local circulation, relieve muscle spasm, can help relieve lumbar protrusion combined with pyriformis syndrome patients pain and local swelling. 3. Drug therapy: non-steroidal anti-inflammatory drugs such as indomethacin and celecoxib, local injections of hormonal drugs such as lidocaine and triamcinolone, muscle relaxants such as epirubicin, and neurotrophic drugs such as methylcobalamin. 4. Surgical treatment: For those who are not effective in conservative treatment, according to the patient’s condition, they can choose pearly muscle amputation, lumbar intervertebral disc removal or fusion surgery. Lumbar protrusion combined with pyriformis syndrome is recommended to go to the hospital in time, early formal treatment, to avoid the adverse consequences. The above drugs should be used under the guidance of a doctor, avoid self-medication.