Carbamazepine can be replaced with regular domestic drugs, but attention needs to be paid to the replacement to ensure that the drug intake is the same, and attention needs to be paid to adverse reactions and contraindications in use. Carbamazepine is mainly used for the treatment of epilepsy, trigeminal neuralgia and other diseases, whether domestic or imported drugs, as long as it is approved by the competent health department of our country to be listed, domestic drugs and imported drugs can be replaced. However, it should be noted that carbamazepine tablets have various specifications such as 0.1g/tablet, 0.2g/tablet, etc. Before and after the replacement, it is necessary to ensure that the effective daily dose of the drug remains unchanged. Replacement of the drug is recommended to be carried out by a professional physician after assessment and re-given a medication regimen based on the new drug. In the administration of carbamazepine, it is recommended to go to the hospital in case of adverse reactions such as headache, ataxia, nausea, thrombocytopenia and urticaria. The drug is contraindicated in cases of drug hypersensitivity, atrioventricular block, severe abnormalities of iron metabolism, bone marrow suppression, hepatic porphyria, as well as severe hepatic impairment, taking monoamine oxidase inhibitors. In principle, this drug is contraindicated in women of childbearing age and during pregnancy. If there is no alternative, it is recommended to use the drug with caution after a full assessment of the benefits and harms. The drug needs to be used under the guidance of a clinician, and it is recommended to consult a physician when changing to a different specification or type of drug.