Eating pomalidomide appeared drug-resistant time appeared no specific point in time, may be 2 years later, may not appear, specifically related to the patient’s own situation, such as sensitivity to drugs and their own immunity. Pomalidomide is the name of a western drug, commonly used in the form of capsules, which is an immunomodulator. Pomalidomide clinically shows unique anti-infection, immunomodulation, anti-angiogenesis, anti-tumor proliferation and other effects, can be used for the treatment of multiple myeloma. Pomalidomide inhibits the proliferation of lenalidomide-resistant multiple myeloma cell lines and acts synergistically with dexamethasone to induce apoptosis of tumor cells in lenalidomide-sensitive and lenalidomide-resistant cell lines. In general, patients taking pomalidomide develop resistance later than with other targeted drugs, such as lenalidomide, which may be about 2 years, or never develop resistance. Of course, the exact time depends on the patient’s situation and physical condition. It is recommended that patients take pomalidomide medication during regular follow-up, if the condition is getting worse, indicating that drug resistance has emerged, at this time, the need to change other suitable treatment options under the guidance of the doctor in a timely manner.