Pain in large teeth without cavities may be periodontal disease, wisdom teeth pericoronitis, maxillary sinusitis, etc. 1. Periodontal disease: Inflammation of the gums and periodontium can lead to bleeding from brushing, swelling and pain, loosening of the teeth, etc. Periodontal treatment is needed. 2. Wisdom tooth pericoronitis: mainly due to wisdom tooth obstruction, the gums overlying it are prone to inflammation, resulting in symptoms such as swelling and pain, and restricted opening. They need to be extracted after controlling the inflammation. 3. Maxillary sinusitis: when the inflammation of the maxillary sinus affects the roots of the maxillary teeth, the discomfort of biting on the back teeth of the maxilla can occur. Need otolaryngology treatment of maxillary sinusitis. It is recommended to go to the regular hospital stomatology consultation, by the physician examination based on the condition of a clear diagnosis and symptomatic treatment.