The most important and fundamental treatment for hepatitis B cirrhosis is antiviral therapy: first, the first-line drugs available are entecavir and tenofovir, which must be taken by patients on a long-term and regular basis; second, patients with cirrhosis can add drugs that soften the liver and disperse nodules as appropriate, such as compound turtle nail soft liver tablets and Fu Zheng Hua Yu capsules, etc. The principle of choosing one is appropriate. Third, in cirrhosis, the liver’s ability to synthesize protein decreases and is mostly accompanied by hypoproteinemia, so oral amino acids can be given. Fourth, for the primary prevention of portal hypertension, propranolol can be chosen to reduce portal pressure, but the heart rate must be monitored during the course of taking the drug. Fifth, if ascites has appeared in cirrhosis, diuretics such as spironolactone and furosemide can be given, but the electrolyte changes must be monitored during the course of taking the medication.