Laughing lines can be removed by injection of Botox, surgery and other ways, but due to individual differences and different treatment effects, some of the treatments can only play a role in improvement. 1. Botox injection: Laughing lines are usually caused by the contraction of expression muscles when smiling. Botox can be injected to block the release of acetylcholine and the conduction between the nerves and the muscles to remove the wrinkles, and the general effect can be maintained for 3~6 months. 2. Surgery: Localized smile lines can be improved through thread sculpture surgery, in which absorbable collagen threads are buried under the skin, thus lifting sagging and loose tissues, and then tightening and removing wrinkles. For people with obvious smile lines, it is recommended that they go to a regular medical institution and choose the appropriate treatment under the guidance of a doctor in order to get the best treatment results.