Walking blisters (blisters) can be treated with general management, physical therapy, and medication. Walking blisters are caused by prolonged walking or walking in an inappropriate way, resulting in local skin friction. 1. General treatment: first of all, patients need to stop walking for a long time, try to wear loose and comfortable shoes, wearing shoes must be suitable and fit. 2. Physical therapy: If the blisters are large, the blisters should be sterilized by a professional doctor and then gently squeezed out or extracted by using a sterile needle to puncture the blister wall, and then sterilized with iodine povidone to prevent local secondary infections. 3. medication: if the affected area has secondary bacterial infection, you can use fusidic acid, erythromycin ointment and other drugs under the guidance of a physician to treat. Walking blisters need to go to the hospital, by the physician according to the patient’s condition for treatment, they can not randomly use drugs.