High amylase may be caused by acute pancreatitis, acute cholecystitis, pancreatic cancer and other diseases. 1. Acute pancreatitis: acute pancreatitis attack can cause serum amylase elevation, and often greater than three times the normal value, is also the main indicator of diagnosis of acute pancreatitis, can also be accompanied by serum lipase elevation. 2. Acute cholecystitis: Acute cholecystitis may cause elevated serum amylase if the inflammation stimulates the pancreas. 3. Pancreatic tumor: Pancreatic tumor compression leads to obstruction of pancreatic duct, which will cause serum amylase elevation. Besides, elevated serum amylase can also be seen in mumps, peptic ulcer perforation and other diseases. It is recommended to go to the hospital to consult a doctor to determine the cause of elevated amylase.