Complex gastric ulcers are a complex gastrointestinal disorder that involves the development of ulcers in both the stomach and the duodenum. The chances of developing cancer in compound gastric ulcers are usually not very high. The clinical manifestations of compound gastric ulcers vary, and some patients may be asymptomatic, or have bleeding, perforation and other complications as the first symptom. Complex gastric ulcers are more common in men than in women. The disease has a high incidence of bleeding but a low rate of malignancy. Complex gastric ulcers can usually be treated with quadruple therapy, proton pump inhibitors (e.g., pantoprazole), antibiotics (e.g., amoxicillin and clarithromycin), and bismuth (e.g., bismuth potassium citrate). Bismuth potassium citrate acts as an anti-inflammatory to protect the gastric mucosa. The symptoms associated with compound gastric ulcers can be effectively relieved by targeted treatment and therefore the chance of developing cancer is low. If gastric ulcer and duodenal ulcer exist at the same time, it is recommended that the patient go to the hospital in time for a clear examination, and then actively cooperate with the doctor to carry out the appropriate treatment.