Pimples at the corners of the mouth generally refer to acne, which can be treated with a light diet, daily care and medication. 1. Light diet: Avoid spicy and stimulating foods, eat a light diet, and eat more fresh vegetables and fruits. 2. Daily care: usually keep the corners of the mouth clean and hygienic, to prevent the corners of the mouth from bacterial infection, every time after eating need to wipe the corners of the mouth clean. 3. medication: medication can follow the doctor’s advice to choose Vitamin A cream, adapalene gel and other drugs; such as moderate to severe acne, oral minocycline, isotretinoin and so on. The corners of the mouth after acne must do a good job of related care, if necessary, can go to the hospital, follow the doctor’s instructions for medication, not to use drugs, so as not to lead to adverse consequences.