The treatment of breast nodules with BI-RADS grade 3 and multiple enlarged lymph nodes in both axillae is decided according to the pathological examination to determine the nature of the nodules, which are usually categorized into benign and malignant nodules, etc. 1. Benign nodes: if the patient is suffering from benign nodes, it is recommended to take medication or surgical resection to alleviate the treatment, the patient can take antibiotic drugs under the guidance of the doctor to carry out the treatment, such as cefixime, levofloxacin, cefaclor, etc., and when the situation is serious, it is possible to carry out surgical resection, which can usually achieve therapeutic results. 2. Malignant nodules: If malignant nodules are diagnosed through pathological examination and the tumor cells have metastasized to the axillary lymph nodes, it is recommended to choose preoperative adjuvant chemotherapy and surgical treatment according to the size of the nodules and molecular typing under the guidance of professional physicians. Patients are advised to maintain a good mood during the recovery process, eat reasonably, do not stay up late, and go to the hospital in time to consult the physician if they feel unwell. The above drugs should be used under the guidance of a physician.