Cirrhosis is the ultimate end of the evolution of chronic liver injury in each, there should be a correct understanding of cirrhosis, on the one hand, we should recognize that once cirrhosis occurs, especially to decompensated cirrhosis can often cause life-threatening complications, so we should pay sufficient attention; on the other hand, we should recognize that there is a long process of liver fibrosis from chronic hepatitis to cirrhosis, we have sufficient time to prevent and We should not live in fear all day long or even give up on ourselves. In fact, with the development of medicine and the in-depth understanding of hepatitis and cirrhosis, there are certain means to prevent and delay cirrhosis, but this requires a common understanding of doctors and patients, tacit cooperation to achieve more desirable results, because just as the development of chronic hepatitis to cirrhosis requires a long-term process, prevention and delay of cirrhosis is a long process, we doctors and patients should have enough confidence and patience. So, how can we make a difference in the long-term process of chronic hepatitis developing into cirrhosis? First of all, we need to have a correct understanding of the occurrence of cirrhosis. The diagnosis of cirrhosis in the compensated stage is not easy, these patients often do not have typical clinical symptoms and signs, and even the laboratory tests of some patients are basically normal, we need a comprehensive examination to determine whether the patient has entered the stage of cirrhosis, such as a decrease in the level of albumin, white blood cell and platelet count below normal values, imaging examinations (including ultrasound and CT, MRI, etc.) show that the liver surface is not Smooth, morphological disorders, thick spleen, etc., or gastroscopy shows that mild varices of esophageal or fundic veins have appeared, these changes are often manifestations of compensated cirrhosis, but some patients are really difficult to judge and need to do liver biopsy pathological examination. And when it comes to decompensated cirrhosis, there are usually complications of different degrees, such as ascites, hepatic encephalopathy, ruptured esophagogastric fundic varices and bleeding. From the above, we can see that the increasing liver fibrosis is the inevitable way of cirrhosis formation. The fibrous tissue in the liver is composed of extracellular matrix (ECM), and these ECM include collagen, non-collagenous protein and proteoglycan composition, and it was previously thought that intrahepatic fibrosis is like the formation of scars after our skin breakage, which is static and unchanging, but in fact, liver fibrosis is a dynamic process, and the generation and When ECM production is greater than degradation, liver fibrosis increases, and vice versa, liver fibrosis decreases. The key role in ECM formation and degradation is recognized to be played by stellate cells in the liver, and the sustained inflammatory response in the liver can produce many inflammatory factors, which can activate stellate cells and cause them to proliferate and produce large amounts of ECM, while the inflammatory response in the liver is often the result of persistent etiological factors, such as persistent viral replication and persistent damage from alcohol or drugs. It follows that the key to preventing and delaying cirrhosis is to reduce liver fibrosis. How to reduce fibrosis in the liver? The first step is to remove the etiology of liver damage, which for hepatitis B and C is aggressive, effective and continuous antiviral therapy, including interferon or nucleoside analogue therapy for HBV and interferon combined with ribavirin for HCV. Only the reduction of viral replication can reduce the expression of viral proteins and also reduce the immunopathological damage against viral proteins, thus fundamentally eliminating the pathological basis of liver fibrosis. Next is aggressive hepatoprotective therapy, such as hepatoprotective drugs containing glycyrrhizin, silymarin, etc. can reduce intrahepatic inflammation and protect liver cells. Then is the Chinese herbal medicine treatment, the ancestral medicine is profound, research shows that many drugs have different degrees of anti-fibrotic effect, they may play a role in reducing liver fibrosis by intervening in different parts of the liver fibrosis process. In addition, it is worth noting that the proper management of chronic hepatitis is a concept that should be strengthened in the diagnosis and treatment of liver disease today, which includes the management of patients by doctors and self-management of patients. The main reason is that the disease progresses more slowly and insidiously, so doctors and patients do not pay enough attention to it.