For patients who are not familiar with assisted reproductive technology may not understand the indications and specific options of IVF, such as not knowing whether they are doing first generation IVF or second generation IVF, and some patients even think that the higher the level of IVF technology, the higher the success rate, which is actually not true. The main difference between first generation, second generation or third generation IVF is that the patients who are adapted to it are different. Today, we will talk to you about these three technologies and their indications and contraindications.
First generation IVF (IVF).
It is what we call conventional IVF, a technique in which the eggs and sperm of the couple with infertility are removed from the body, the sperm is washed so that the eggs are fertilized in the in vitro system and developed into embryos, and then the embryos are transferred into the uterine cavity to achieve pregnancy. The fertilization of eggs in this procedure is close to the fertilization of eggs in a natural pregnancy.
Indications
1.Disorders of egg transport caused by various factors in the female side, such as bilateral tubal obstruction, tubal agenesis, severe pelvic adhesions and other tubal loss;
2, Ovulation disorder: refractory ovulation disorder after repeated conventional treatment, such as repeated induction of ovulation or combined with intrauterine insemination treatment, but still did not obtain a pregnancy;
3. Endometriosis: endometriosis that has not resulted in pregnancy after conventional drug or surgical treatment;
4.Male factor infertility: male infertility with oligo-teratogenic spermatozoa or compound factors, who have not obtained pregnancy after intrauterine insemination treatment, or whose male partner is not suitable for intrauterine insemination in terms of severity of factors;
5. Immunological infertility and unexplained infertility: those who have repeatedly failed to obtain pregnancy after intrauterine insemination treatment or other conventional treatments, etc.
Second generation IVF (ICSI).
Intracytoplasmic single sperm injection is the injection of a single sperm into the oocyte plasma by microinjection, thus is to make the sperm and oocyte passively united for fertilization, forming a fertilized egg and embryo transfer to achieve pregnancy.
Indications
1. Severe oligo- and hypospermia;
2, irreversible obstructive azoospermia;
3, spermatogenic dysfunction (excluding genetic defects caused by disease);
4, immune infertility;
5, conventional IVF fertilization failure, or very low fertilization rate;
6, sperm acrosome abnormalities and other conditions. For embryos, ICSI is an invasive treatment, so it is limited to those who are necessary.
Third Generation IVF (PGD).
Pre-implantation embryo genetic diagnosis means taking some cells from embryos fertilized in vitro for genetic testing to exclude embryos with disease-causing genes before transfer.
Indications
1, Patients with abnormal chromosome number or structure;
2. One of the spouses is a carrier of a sex-linked heritage disease (e.g. hemophilia, pseudohypertrophic muscular dystrophy);
3. Patients or carriers of monogenic diseases for which genetic diagnosis is available, etc.
Contraindications to assisted reproductive technology.
1. Serious mental illness, acute infection of the genitourinary system and sexually transmitted diseases in either sex;
2.Hereditary diseases that are not suitable for childbirth and cannot be diagnosed prenatally or by pre-implantation genetics as stipulated in the Maternal and Child Health Law;
3, either spouse has a serious drug addiction and other bad habits;
4, either spouse is exposed to teratogenic amount of radiation, toxins, drugs and in the period of action;
5, the female uterus does not have pregnancy function or serious physical disease can not bear pregnancy or have other contraindications to IVF-ET couples.
After the introduction of this knowledge I believe that you have a certain understanding of IVF treatment, in the selection of the program should also try to listen to the advice of the attending doctor to choose the right program for your treatment.