Sore legs and feet after walking is a situation that many older people often encounter, perhaps most people feel that this is very normal, the age of well! But did you know? This soreness may indicate a potential disease, lower limb atherosclerosis occlusive disease. The disease is characterized by an insidious onset in the early stages, but once it reaches the middle and late stages, it can cause severe pain and even necrosis in the affected limb due to severe ischemia, and a significant number of patients have to undergo amputation, thus seriously affecting the quality of life. Because the disease is often associated with coronary heart disease, diabetes and cerebrovascular disease, it has a high mortality rate. With the improvement of people’s living standard, the per capita life expectancy in China has reached over 70 years old, coupled with the increase in the proportion of fat in the diet structure, the incidence of atherosclerosis has increased significantly. Excess lipid components in the blood are continuously deposited on the arterial walls as irregularly shaped atheromatous plaques, causing the arterial lumen to become increasingly narrow, affecting the blood supply to the limbs and putting the nerves, muscles and skin of the lower limbs and other tissues in an increasingly heavy ischemic environment. In the early stage of the disease, the need for oxygen of the lower limb muscles increases when the patient walks, so it is in a relatively hypoxic state, and then anaerobic metabolism occurs, generating lactic acid and other metabolites to stimulate the nerves and the soreness of the affected limbs, especially the calf muscles. At this time, if the patient sits down and takes a short break, the soreness can be relieved or disappeared, but the pain will be aggravated after walking a certain distance again, which is called intermittent claudication. The more severe the arterial stenosis, the shorter the walking distance the patient can tolerate, until finally losing the ability to walk. In the later stages of the disease, the artery may even be occluded, and then even at rest the limb is in a state of extreme ischemia, producing severe pain in the nerve endings, called resting pain, especially at night, so such patients often cannot sleep all night because of severe pain, causing great suffering. At the same time, ischemia of skin and muscle tissue gradually loses its vitality, resulting in ulceration or black gangrene of the affected foot, especially the toes, and recurrent infection of the necrotic area is often uncontrollable with general drugs, resulting in the so-called old rotten feet. As with most diseases, the treatment of lower extremity atherosclerosis occlusive disease should be detected early and treated early. In the early stage of atherosclerotic stenosis, anticoagulation, de-agglomeration or vasodilator drugs can be used to promote blood flow and correct tissue ischemia, while appropriate walking exercises can be used to enhance the tolerance of the lower extremity tissues to ischemia, and to promote the formation and opening of collateral vessels around the occluded artery. Once the disease enters the stage of resting pain or foot gangrene, the patient should be seen by a vascular surgeon as soon as possible, and the main treatment method is to reconstruct the blood supply to the affected limb through surgery. Currently, surgical methods include traditional surgery to replace an occluded artery with an artificial vessel and endoluminal revascularization (using a needle to insert into the artery to establish a vascular channel, dilating the narrowed vessel through endovascular manipulation, and placing a stent to open the vessel to improve blood flow). Each of them has its own indications, and the latter has become the direction of vascular surgery development with its minimally invasive feature, especially suitable for the old and frail. Therefore, early detection of the traces of lower extremity atherosclerosis occlusive disease, early vascular surgery specialist diagnosis and treatment is very beneficial.