Obvious thickening of the wall of duodenal bulb may be duodenitis, duodenal ulcer, duodenal cancer and other diseases, which need to be treated with medication, surgery, radiotherapy and other ways according to the cause. 1. Duodenitis: common symptoms include abdominal pain, acid reflux, belching and so on. Patients need to apply gastrointestinal dynamics drugs such as domperidone and mosapride, and proton pump inhibitors such as omeprazole and rabeprazole according to medical advice. For patients who are not effective in drug treatment, surgical treatments such as vagotomy and highly selective vagotomy should be considered. 2. Duodenal ulcer: the main symptoms are epigastric pain, heartburn, loss of appetite. Patients need to follow the doctor’s instructions to apply magnesium carbonate, aluminum hydroxide and other gastric mucosal protective agents, as well as lansoprazole, esomeprazole and other proton pump inhibitors, as well as ranitidine, cimetidine and other H2 receptor antagonists. For those who are ineffective in internal medicine treatment and have complications such as perforation and pyloric obstruction, surgical treatment such as duodenal perforation repair, pyloroplasty or gastrointestinal anastomosis is needed. 3. Duodenal cancer: typical symptoms include jaundice, nausea, vomiting and abdominal pain. Clinical surgical treatments for this disease include endoscopic mucosal resection, gastrojejunostomy, T-tube bridging and drainage. Secondly, those who undergo surgery also need to take radiation therapy, which is often used as an adjunctive treatment to surgery. When the patient examines the existence of duodenal bulb wall thickening, need to do further examination, clear specific causes, with the doctor in accordance with the doctor’s instructions active treatment.