The need for medication for H. pylori has less to do with the severity of the infection and more to do with the disease. Eradication therapy is recommended for anyone who is H. pylori positive without resistance factors (advanced age, etc.). Eradication therapy is strongly recommended in the presence of peptic ulcer, gastric mucosa-associated lymphoid tissue lymphoma, chronic gastritis with dyspeptic symptoms, chronic gastritis with gastric mucosal atrophy, erosion, family history of gastric cancer, long-term use of proton pump inhibitors, and long-term use of non-steroidal anti-inflammatory drugs. The currently recommended eradication regimen is a quadruple therapy consisting of two antibiotics, a proton pump inhibitor, and a bismuth agent. Commonly used drugs include amoxicillin, clarithromycin, omeprazole, rabeprazole, and bismuth potassium citrate. Common adverse effects of taking quadruple therapy include bloating, abdominal pain, constipation, and loss of appetite, in addition to blackening of the tongue and darkening of the stool because of the bismuth content. The presence of positive Helicobacter pylori, it is recommended to go to the hospital, under the guidance of a professional doctor anti-Helicobacter pylori treatment, do not because it is only a minor infection without treatment.