Ibuprofen can treat painful urination, it is a kind of non-steroidal pain relieving drug, after oral consumption will not cause the patient’s addiction, can treat mild to moderate pain, including painful urination, but it is only a symptomatic pain relieving drug, not for the treatment of the cause of the drug. It is recommended that patients go to the hospital for relevant examinations to clarify the causes of urinary pain, and then with the cause of the treatment of drugs for synergistic treatment. If the pain is obvious, oral ibuprofen can be taken to relieve the pain of urination, reduce the patient’s symptoms and improve the patient’s quality of life. If it is clear that the painful urination is caused by stones, then extracorporeal shock wave lithotripsy should be performed, and then oral pain relief or stone removal drugs should be taken to control the symptoms and eliminate the stones. If the painful urination is caused by infection, then in addition to oral ibuprofen for pain relief, oral anti-infective drugs should also be taken. It is best to choose antimicrobials to treat the infection according to the results of urine culture and drug sensitivity test, and the painful urination can be cured after the infection is cured.