Midnight itchy skin on the extremities consider pruritus, urticaria caused by the following: 1, pruritus: only itching and secondary rash damage, such as scratch marks, blood scabs, scales, etc., due to the sebaceous glands secretion function is weakened, dry skin caused by, or secondary to severe diabetes, hypertension, cerebral thrombosis and other medical diseases. Patients can apply glyburide lotion or menthol lotion and take oral olopatadine hydrochloride tablets or fexofenadine hydrochloride tablets for anti-allergic treatment; 2. Urticaria: In addition to itching, wind clusters and edematous erythema can appear, and patients can take oral Avastin capsules and use topical glyburide lotion for treatment.