High N-Acetyl-β-D Aminoglucosidase is usually caused by glomerulonephritis, interstitial nephritis, lupus nephritis. The treatment means are different for different causes, so it is recommended to go to the hospital in time for targeted diagnosis and treatment under the guidance of doctors. 1. Glomerulonephritis: it may be caused by heredity, viral infection and low immunity, and can be treated with drugs such as hydrochlorothiazide, dexamethasone, penicillin, dipyridamole and so on under the guidance of doctors. 2. Interstitial nephritis: interstitial nephritis may be caused by long-term use of certain drugs, you can take cefixime capsules, rutin tablets, leflunomide tablets under the guidance of the doctor for treatment. 3. Lupus nephritis: lupus nephritis is an autoimmune disease, you can take leflunomide tablets, cyclosporine soft capsules and other drugs under the guidance of a doctor for treatment. The above medications are for reference only, there are other medications that can relieve the symptoms. In addition, all drugs have certain side effects, but also in accordance with the doctor’s prescribed treatment program and method of medication, not self-medication.