There are accidents everywhere in life, and also because of the arrival of certain accidents, some trauma is caused to people’s body. Currently there are many people who need to undergo craniotomy because of a traumatic brain injury due to an accident, and after craniotomy hand debridement surgery, some patients have cranial defect problem. Cranial defect has a great impact on health because the skull is an important umbrella for brain tissue, once the skull is defective, the brain tissue lacks protection and is easily attacked by the outside world. After skull defect, it is very necessary to do skull repair surgery, but patients should seize the best time to repair, so as to recover better. Generally speaking, if a patient has a giant cranial defect caused by decompression of the large bone flap for cranial hypertension, the cranial repair surgery must be done after 3 months after the surgery, which is the best time. However, in addition to the timing of the skull repair surgery, the choice of the skull repair material is also very critical, and the material directly affects the success or failure of the surgery. From ancient times to now, there are many materials used for skull repair, like early bone cement and animal bone, but they have been eliminated long ago because of various defects. And now most of the hospitals are using titanium mesh material, which is much more progressive compared with the traditional material, but there are some inevitable problems, and patients should choose carefully. According to the survey, the more ideal material for skull repair surgery is polyether ether ketone PEEK material, which is an advanced polymer material, safer and more reliable than titanium mesh material, its performance is excellent, even with the autologous cranial bone, choose this material for skull repair surgery is more than good.