Waking up with pain in the temples can be due to both physiologic and disease factors. Physiological factors are mostly seen in poor sleep quality, stay up late patients, disease factors are many, mostly seen in hypertension, upper respiratory tract infection, migraine and other factors. 1. Physiological factors: poor sleep quality, stay up late and other physiological factors will lead to the brain in a long time in the state of fatigue, easy to cause cerebral vasospasm, which leads to pain in the temples after waking up. 2. Hypertension: morning pain in the temple area, the most common disease to consider abnormal blood pressure, because early in the morning is the time period when blood pressure is most likely to rise, if the temple manifests itself as a vascular throbbing pain, you need to monitor the blood pressure, and through the use of antihypertensive drugs, such as amlodipine, nifedipine, to control the blood pressure stable after the improvement of the symptom. 3. Upper respiratory tract infections: pain in the temple area in the morning, may also be due to cold at night caused by cold fever, body temperature abnormalities caused by the patient is often accompanied by sore throat, runny nose, sneezing and other symptoms. 4. Migraine: patients with a history of recurrent headaches, in poor sleep or fatigue and other triggers are prone to migraine attacks, will show a moderate to severe throbbing pain in the temples. Waking up with pain in the temples may also be cerebrovascular accident, sleep apnea syndrome and many other diseases. Therefore, the cause of pain in the temples after waking up is very complex, need to be combined with the patient’s accompanying symptoms, improve the relevant examination, clear the cause of the disease under the guidance of the doctor for medication.