Pain in the middle of the backbone may be caused by physiological factors or by certain diseases, such as osteoporosis and ankylosing spondylitis. 1. Physiological factors: prolonged bending, heavy physical labor or prolonged sedentary work leads to muscle strain and inflammation of the fascia of the low back, which in turn leads to pain. 2. Osteoporosis: the amount of bone decreases, the microstructure of bone tissue degenerates, and the trabeculae of cancellous bone become thin, broken, and reduced in number, which in turn causes pain. 3. Ankylosing spondylitis: when patients are affected by inflammation, it manifests as dull pain in the lumbosacral region or back, accompanied by morning stiffness, fatigue, weakness and other manifestations. If the pain in the middle of the backbone is caused by physiological factors, proper rest and attention to work and rest can be relieved. Tumors and rheumatic diseases can also cause pain in the middle of the backbone. If the pain is caused by physiological factors, it is recommended to consult a doctor in time and follow the doctor’s instructions to standardize the treatment.