A kidney biopsy is an invasive test, usually performed by puncturing a needle into the kidney under ultrasound guidance and removing a piece of living kidney tissue from the patient’s lower back, so a kidney biopsy is invasive and painful. Anesthesia is used when performing a kidney biopsy. The use of local anesthesia can reduce the patient’s pain and allow the patient to tolerate the kidney biopsy. It is not possible to anesthetize into the kidney, but a local anesthetic is used between the skin and the kidney tissue. To date, no one has been found to be unable to tolerate the pain of a kidney biopsy and has taken other anesthetic methods such as general anesthesia to perform a kidney biopsy. Usually the patient is less damaged with local anesthesia and the biopsy tissue is taken more smoothly, so the pain should be tolerable. If the patient is in pain after the kidney biopsy, analgesia can be used to allow the patient to spend 24 hours and the pain will basically be relieved.